5-Azacytidine (5-aza-C) analogs demonstrate a remarkable ability to induce heritable
changes in gene and phenotypic expression. These cellular processes are associated with …

We demonstrate that DNA methylation in an adrenocortical tumor cell line, Y1, is controlled
by the Ras signaling pathway. Forced expression of a cDNA encoding human GAP 120 …

Background. The authors' previous investigations using living cultured human cancer cells
and cells isolated from cancer tissues, analytical flow cytometry, and monoclonal antibodies …

The differentiated state of specialized cells appears to be dependent on interactions
between the extracellular microenvironment, cytoplasmic signals and DNA. Perturbations in …

Many tumor cell lines overexpress DNA methyltransferase (MeTase) activity; however it is
still unclear whether this increase in DNA MeTase activity plays a causal role in naturally …

We have previously shown that in developing chicken embryos and differentiating mouse
myoblasts, the demethylation of 5-metCpGs occurs through the replacement of 5 …

Repeat-induced point mutation (RIP) is a process that efficiently detects DNA duplications
prior to meiosis in Neurospora crassa and peppers them with G: C to A: T mutations …

Global and gene-specific DNA hypomethylation is considered to be an important early
epigenetic event in several human neoplasms. A growing body of evidence has suggested …

Carbon tetrachloride (CC14) administration to rats produces hepatic cirrhosis and
supplementation with S-adenosylmethionine (SAM) can partially prevent CCl4-induced liver …

Higher intakes of folic acid-rich foods such as vegetables, legumes, and whole grains are
associated with lower incidence of carcinomas in international comparisons and case …