I n this issue, Sallusto et al.(1) report that dendritic cells. can vigorously internalize solutes by
macropinocytosis, delivering these to MHC class II-rich vesicles (MIIVs). In the most familiar …

We have previously demonstrated that human peripheral blood low density mononuclear
cells cultured in granulocyte/macrophage colony-stimulating factor (GM-CSF) and …

Dendritic cells are APCs that are unique in their potency to stimulate proliferation of primary
Ag-specific responses in vitro and in vivo. In this study, we demonstrate that dendritic cells …

The development of recombinant DNA technologies has generated remarkable insight into
the mechanisms underlying carcinogenesis. The recognition that specific mutations in …

Molecules of the TNF-R family have been shown to be essential in the regulation of
lymphocyte growth and differentiation. The TNF-R family member CD27 binds to a type II …

It has previously been shown that bone marrow-generated dendritic cells (DC) are potent
stimulators in allogeneic mixed leukocyte reactions and are capable of activating naive …

Exogenous glucocorticoid hormones are widely used as therapeutical agents, whereas
endogenous glucocorticoids may act as physiological immunosuppressants involved in the …

Dendritic cells are the most potent antigen-presenting cells of the immune system. Although
dendritic cells are likely to secrete selective cytokines that facilitate antigen presentation, the …

Dendritic cells (DC) are specialized antigen-presenting leukocytes that are responsible for
the activation of naive as well as memory T lymphocytes. If infected by human …

Dendritic cells (DC) represent potent antigen-presenting cells for the induction of T cell-
dependent immune responses. Previous work on antigen uptake and presentation by …