The contribution of extrapancreatic effects of sulfonylureas to the blood glucose-decreasing
activity was re-evaluated in vivo and in vitro with several conventional sulfonylureas and …

I. Introduction G LUCOSE is the primary energy source for the brain under normal
physiological circumstances and is acutely taken up by other mammalian cells for immediate …

The insulin-regulated glucose transporter isotype GluT4 expressed only in muscle and
adipose cells is sequestered in a specific secretory vesicle. These vesicles harbor another …

Glucosamine (Glmn), a product of glucose metabolism via the hexosamine pathway, causes
insulin resistance in isolated adipocytes by impairing insulin-induced GLUT 4 glucose …

The effect of magnesium deficiency on glucose disposal, glucose-stimulated insulin
secretion and insulin action on skeletal muscle was investigated in rats which were fed a low …

The effect of increased Glut4 protein expression in muscle and fat on the whole body
glucose metabolism has been evaluated by the euglycemic hyperinsulinemic clamp …

The facilitated diffusion of d-glucose across the plasma membrane is carried out by a set of
stereospecific transport proteins known as the glucose transporters. These integral …

Chronic hyperinsulinemia with maintenance of euglycemia was imposed on normal rats for
4 days. In white adipose tissue, hyperinsulinemia resulted in a twofold increase in GLUT4 …

ob gene regulation is as yet unknown. We first examined whether the ob gene is under
physiological control by the nutritional state. Fasting produced a sharp (95%) decrease of ob …

Recent experimental evidence has focused attention to the role of two molecules, insulin
receptor substrate 1 (IRS-1) and phosphatidylinositol 3-kinase (PI3-kinase), in linking the …