We have validated a noninvasive computerized tail-cuff system for measuring blood
pressure in mice. The system was designed to perform all functions automatically, including …

Variants of the human angiotensinogen gene have been linked in some studies to increased
circulating angiotensinogen levels and essential hypertension. To test for direct causality …

ALTHOUGH pharmacological doses of retinoic acid (RA) have a wide variety of actions in
vivo 1, experimental difficulties have prevented a definitive assignment of its physiological …

The renin-angiotensin system (RAS) plays a key role in the regulation of the circulation and
is critically involved in the pathogenesis of several diseases, including hypertension. Renin …

Essential hypertension is one of the most common diseases that exacerbate the risk of
cardiovascular or cerebrovascular attacks. Although the etiology of essential hypertension …

The renin-angiotensin system plays an important role in blood pressure regulation.
Angiotensinogen, which is mainly produced in the liver, is a unique component of the renin …

Since its first description in 1981 (1), transgenic technology has greatly influenced the focus
and direction pace of biomedical research. Introduction of foreign DNA into the genome of …

Although essential hypertension has long been recognized to involve a strong genetic
predisposition, the genes that increase susceptibility remain virtually unknown. With recent …

The renin-angiotensin system, composed of enzymatic and signaltransduction cascades,
plays a key role in the regulation of arterial blood pressure and in the development of certain …

Publisher Summary This chapter concentrates on the technical aspects of establishing an
animal model. The different methods have been outlined, references for detailed …