Construction of a bispecific single-chain antibody derivative is described that consists of two
different single-chain Fv fragments joined through a Gly-Ser linker. One specificity of the two …

Background: The high frequency of relapse after induction chemotherapy of advanced
ovarian carcinoma calls for new therapeutic approaches. Lysis of ovarian carcinoma cells …

PURPOSE MDX-210 is a bispecific antibody that binds simultaneously to type I Fc receptors
for immunoglobulin G (IgG)(Fc gamma RI) and to the HER-2/neu oncogene protein product …

Many strategies for experimental immunotherapy of cancers aim at inducing and expanding
tumor-specific cytotoxic T-lymphocytes. One of the most promising approaches uses …

We have studied the cytotoxic activity of rat basophilic leukemia (RBL) cells transfected with
cDNAs for the cytotoxic T lymphocyte (CTL) granule components, cytolysin (perforin) …

Induction of T-cell activation requires multiple signals provided by cell surface receptor
interactions and/or cytokines. T-cell stimulation via the T-cell receptor/CD3 complex provides …

Bispecific monoclonal antibodies, with a dual specificity for tumor associated antigens on
target cells and for surface markers on immune effector cells, have been shown (in vitro) to …

The anti-tumour x anli-T-cell bispecific monoclonal antibody (hiMAh) ОС/TR is a biologically
produced hiMAb combining the anti-ovarian carcinoma activity of lhe MOvlH MAb with anti …

1 Gruber & Durham (1896), Widal & Sicard (1896) and Kraus (1897) published some of the
earliest immunological diagnostic techniques. Paul Ehrlich, however, has been described as …

Cytotoxic CD8+ T cells and NK cells play a role in the elimination of some viruses, graft
rejection, antitumour responses, immuno regulation and some autoimmune diseases. The …