Meta‐analyses using updated individual patient data may provide the most reliable means
of combining data from similar randomized controlled trials. The benefits of this approach to …

WHERE SHOULD a physician look to find accurate, up-to-date information about the
effectiveness of a variety of clinical interventions? At the bedside or in the office, physicians …

Objective.—To compare the meta-analytic results from published literature vs those obtained
from pooling original patient data. Data Sources.—Individual patient data from 15 completed …

In this issue ofTHE JOURNAL, Jeng et al 1 report discrepancies between the results of meta-
analyses using aggregate data available from the literature (MAL) and meta-analyses using …

There are a large number of clinical research designs that have stood the test of time. There
is no single research design that is best to answer all research questions, and every …

If the relative effectiveness of different treatments that might be used in clinical practice is to
be evaluated reliably, it is very important that the evaluation is carried out in an appropriate …

Annals of Internal Medicine is the principal “voice” of internal medicine. My challenge as its
new Editor will be to help move Annals from its present level of excellence to new heights …

The number of meta-analyses or overviews appearing in the literature is rapidly increasing.
Because of the problems inherent in non-randomised studies, which are not diminished by …

Trad" rade and exchange-peaceful means by rade and exchange-peaceful means by which
people obtain goods not available are mechanisms complementary to resource …

Worldwide, hundreds of thousands of premature deaths a year could be avoided by seeking
large-scale randomized evidence about various widely practicable treatments for the …