Purpose: To review prospective epidemiologic studies and randomized trials regarding the
role of antioxidant vitamins (vitamins E and C and β-carotene) in the prevention of …

The antioxidant hypothesis postulates that suboptimal levels of principal antioxidant
micronutrients are hitherto underrated risk factors for cardiovascular diseases …

Background: Several human studies have observed a direct association between retinol
(vitamin A) intake and risk of prostate cancer; other studies have found either an inverse …

Objective: To determine whether physical inactivity and obesity increase risk for colon
cancer and adenomas, which are precursors of cancer, and whether the abdominal …

Obesity, android fat distribution, and other anthropometric measures have been associated
with coronary heart disease in long-term prospective studies. However, fluctuations in …

Background Epidemiologic studies have identified hyperhomocysteinemia as a possible risk
factor for atherosclerosis. We determined the risk of carotid-artery atherosclerosis in relation …

Objective: To examine the association between smoking, alcohol consumption, and the
incidence of non-insulin dependent diabetes mellitus in men of middle years and older …

Background: Methylation of DNA, which may have a role in the regulation of gene
expression, depends on dietary folate and methionine. Because aberrant DNA methylation …

Objective To develop a self-administered food frequency questionnaire for older children
and adolescents and to demonstrate reproducibility over a 1-year period. Design The …

Background It has been hypothesized that a diet containing n-3 fatty acids from fish reduces
the risk of coronary heart disease, but few large epidemiologic studies have examined this …