Receptors for the vitamin folic acid are frequently overexpressed on epithelial cancer cells.
To examine whether this overexpression might be exploited to specifically deliver liposome …

Antisense oligodeoxyribonucleotides targeted to the epidermal growth factor (EGF) receptor
were encapsulated into liposomes linked to folate via a polyethylene glycol spacer (folate …

We are utilizing the folate receptor for the intracellular delivery of DNA. In this study, a
folatepoly-L-lysine (FPLL) conjugate was synthesized and equilibrated with plasmid DNA …

A novel, structurally defined, and homogeneous oligodeoxynucleoside methylphosphonate
(oligo-MP) neoglycopeptide conjugate,[YEE (ah-GalNAc) 3]-SMCC-AET-pUmpT7, has been …

Publisher Summary Classical phenylketonuria (PKU) was first recognized as a distinct
metabolic disorder causing severe, irreversible mental retardation by the Norwegian …

The human immunodeficiency virus-1 Tat protein can efficiently enter cells when added
exogenously in tissue culture. Using the transactivation activity of Tat as a measure of …

Caveolae are 50–100 nm invaginations that represent a sub-compartment of the plasma
membrane. Recent studies have implicated these membranous structures in:(1) transcytosis …

Background: The folate receptor is a 38 to 39 kd glycoprotein attached to the cell membrane
via a glycosylphos-phatidylinositol anchor. It serves as the initiation point for receptor …

The mechanism of folate uptake, mediated by the high-affinity folate receptor linked via
glycosylphosphatidylinositol to the plasma membrane of L1210 mouse leukemia cells, has …

Interest in gene therapy arises from the realization that, for many human diseases, current
treatment of human disease, genetic or otherwise, is generally aimed at symptoms or …