Structural basis of substrate specificity in the serine proteases
Abstract Structure‐based mutational analysis of serine protease specificity has produced a
large database of information useful in addressing biological function and in establishing a …
large database of information useful in addressing biological function and in establishing a …
A hot spot of binding energy in a hormone-receptor interface
T Clackson, JA Wells - Science, 1995 - science.org
The x-ray crystal structure of the complex between human growth hormone (hGH) and the
extracellular domain of its first bound receptor (hGHbp) shows that about 30 side chains …
extracellular domain of its first bound receptor (hGHbp) shows that about 30 side chains …
NMR–this other method for protein and nucleic acid structure determination
K Wüthrich - Acta Crystallographica Section D: Biological …, 1995 - scripts.iucr.org
For a quarter of a century X-ray diffraction in single crystals was unique in its ability to solve
three-dimensional structures of proteins and nucleic acids at atomic resolution. The situation …
three-dimensional structures of proteins and nucleic acids at atomic resolution. The situation …
[3] Macromolecules and water: Probing with osmotic stress
VA Parsegian, RP Rand, DC Rau - Methods in enzymology, 1995 - Elsevier
Publisher Summary This chapter presents specific examples to describe procedures and
use osmotic stress with maximum ease and efficiency. These examples are systems where …
use osmotic stress with maximum ease and efficiency. These examples are systems where …
B-DNA twisting correlates with base-pair morphology
AA Gorin, VB Zhurkin, K Wilma - Journal of molecular biology, 1995 - Elsevier
The observed sequence dependence of the mean twist angles in 38B-DNA crystal structures
can be understood in terms of simple geometrical features of the constituent base-pairs …
can be understood in terms of simple geometrical features of the constituent base-pairs …
Solution structure of the epithelial cadherin domain responsible for selective cell adhesion
Cadherins are calcium-dependent cell adhesion molecules containing extracellular repeats
of approximately 110 amino acids. The three-dimensional structure of the amino-terminal …
of approximately 110 amino acids. The three-dimensional structure of the amino-terminal …
High resolution crystal structure of a paired (Pax) class cooperative homeodomain dimer on DNA
The crystal structure of the paired homeodomain bound to DNA as a cooperative dimer has
been determined to 2.0 A resolution. Direct contacts between each homeodomain and the …
been determined to 2.0 A resolution. Direct contacts between each homeodomain and the …
The Complex formed between tet repressor and tetracycline-Mg2| ihsbop|+ reveals mechanism of antibiotic resistance
C Kisker, W Hinrichs, K Tovar, W Hillen… - Journal of molecular …, 1995 - Elsevier
In recent years Gram-negative bacteria have developed several resistance mechanisms
against the broad-spectrum antibiotic tetracycline (Tc). The most abundant mechanism …
against the broad-spectrum antibiotic tetracycline (Tc). The most abundant mechanism …
Structure of Bam HI endonuclease bound to DNA: partial folding and unfolding on DNA binding
M Newman, T Strzelecka, LF Dorner, I Schildkraut… - Science, 1995 - science.org
The crystal structure of restriction endonuclease Bam HI complexed to DNA has been
determined at 2.2 angstrom resolution. The DNA binds in the cleft and retains a B-DNA type …
determined at 2.2 angstrom resolution. The DNA binds in the cleft and retains a B-DNA type …
Comprehensive analysis of hydrogen bonds in regulatory protein DNA-complexes: in search of common principles
Y Mandel-Gutfreund, O Schueler, H Margalit - Journal of molecular biology, 1995 - Elsevier
A systematic analysis of hydrogen bonds between regulatory proteins and their DNA targets
is presented, based on 28 crystallographically solved complexes. All possible hydrogen …
is presented, based on 28 crystallographically solved complexes. All possible hydrogen …