Abstract Structure‐based mutational analysis of serine protease specificity has produced a
large database of information useful in addressing biological function and in establishing a …

The x-ray crystal structure of the complex between human growth hormone (hGH) and the
extracellular domain of its first bound receptor (hGHbp) shows that about 30 side chains …

For a quarter of a century X-ray diffraction in single crystals was unique in its ability to solve
three-dimensional structures of proteins and nucleic acids at atomic resolution. The situation …

Publisher Summary This chapter presents specific examples to describe procedures and
use osmotic stress with maximum ease and efficiency. These examples are systems where …

The observed sequence dependence of the mean twist angles in 38B-DNA crystal structures
can be understood in terms of simple geometrical features of the constituent base-pairs …

Cadherins are calcium-dependent cell adhesion molecules containing extracellular repeats
of approximately 110 amino acids. The three-dimensional structure of the amino-terminal …

The crystal structure of the paired homeodomain bound to DNA as a cooperative dimer has
been determined to 2.0 A resolution. Direct contacts between each homeodomain and the …

In recent years Gram-negative bacteria have developed several resistance mechanisms
against the broad-spectrum antibiotic tetracycline (Tc). The most abundant mechanism …

The crystal structure of restriction endonuclease Bam HI complexed to DNA has been
determined at 2.2 angstrom resolution. The DNA binds in the cleft and retains a B-DNA type …

A systematic analysis of hydrogen bonds between regulatory proteins and their DNA targets
is presented, based on 28 crystallographically solved complexes. All possible hydrogen …