The cholinergic hypothesis claims that the decline in cognitive functions in dementia is
predominantly related to a decrease in cholinergic neurotransmission. This hypothesis has …

Research on the neuropsychology of aging and memory is concerned with changes in
memory with age that are related to corresponding changes in the nervous system. Studies …

Primates are unique among mammals in possessing a region of dorsolateral prefrontal
cortex with a well-developed internal granular layer. This region is commonly implicated in …

The emotional reactivity of rats with lesions of the dorsal portion of medial prefrontal cortex
(mPFC) was examined using a classical fear conditioning paradigm. Conditioned fear …

In order to compare the frontal cortex of rat and macaque monkey, cortical and subcortical
afferents to subdivisions of the medial frontal cortex (MFC) in the rat were analyzed with …

1. Extracellular spike activity was recorded from 1,942 single neurons in orbitofrontal cortex
(OF) and 591 single neurons in pyriform cortex (PIR) over multiple sessions in rats …

The effects of reversible lidocaine-induced lesions of 2 subregions of the rat medial
prefrontal cortex (mPFC) were examined on a series of cognitively based foraging behaviors …

Rats with medial prefrontal cortical lesions were tested in a modified water maze navigation
task. In Stage 1, the rats were trained to locate a hidden platform from a single start location …

The functional influence of the frontal cortex (FC) on the noradrenergic nucleus locus
coeruleus (LC) was studied in the rat under ketamine anesthesia. The FC was inactivated by …

An in vivo autoradiographic procedure was employed to visualize local changes in brain
opioid receptor occupancy in juvenile rats. This procedure is based on the assumption that …