There is considerable evidence that high novelty seekers are at increased risk for using
drugs of abuse relative to low novelty seekers. This review examines the potential biological …

Drug abuse is a major public health problem, and the relationship between intravenous drug
abuse and AIDS underscores the need for more effective treatment medications. Animal …

The present study investigated the ability of drug-associated cues to reinstate extinguished
responding following an extended period of withdrawal from cocaine self-administration …

The effects of blockade of opioid and dopamine receptors on relapse to heroin-seeking
induced by footshock stress and re-exposure to heroin were examined in a reinstatement …

TOMIE, A. Locating reward cue at response manipulandum (CAM) induces symptoms of
drug abuse. NEUROSCI BIOBEHAV REV 20 (3) 505–535, 1996.—Appetitive instrumental …

ABSTRACT ABBREVIATIONS: ANOVA, analysis of variance; ARCI, Addiction Research
Center Inventory; AUC, area-under-the-curve; HIV, human immuno-deficiency virus; LSD …

The involvement of mesolimbic dopamine (DA) systems in motivational aspects of drug-
taking behavior during initiation of drug self-administration was investigated using a recently …

The ability of the κ-opioid receptor agonist trans-(±)-3, 4-dichloro-N-methyl-N-[2-(1-
pyrrolidinyl)-cyclohexyl]-benzeneacetamide methanesulfonate (U-50,488) to modulate …

In the first experiment, responding was maintained for food under a fixed ratio (FR) 10 with a
6-mm timeout reinforcement schedule. Eticlopride(0.1-1. 0 mg/kg ip) dose-dependently …

Repeated administration of cocaine led to increases in ambulation-accelerating activity
(sensitization) and conditioned place preference (CPP). Dopamine (DA)-receptor …