▪ Abstract The past few years have seen a wider acceptance of a role for DNA methylation in
cancer. This can be attributed to three developments. First, the documentation of the over …

There are two biological properties of genomic methylation patterns that can be regarded as
established. First, methylation of 5′-CpG-3′ dinucleotides within promoters represses …

Recent studies showing a correlation between the levels of DNA (cytosine-5-)-
methyltransferase (DNA MTase) enzyme activity and tumorigenicity have implicated this …

The immunoglobulin κ gene is specifically demethylated during B–cell maturation in a
process which utilizes discrete cis–acting modules such as the intronic κ enhancer element …

An in vitro system for studying DNA demethylation has been established using extracts from
tissue culture cells. This reaction, which is unusually resistant to proteinase K, takes place …

DNA methylation is now recognized as an important mechanism regulating different
functions of the genome; gene expression, replication, and cancer. Different factors control …

The formation of DNA photoproducts by ultraviolet (UV) light is responsible for the induction
of mutations and the development of skin cancer. Cis− syn cyclobutane pyrimidine dimers …

Multiple roles for DNA methylation in gametic imprinting Bjorn Neumann* and Denise P Barlowt
Page 1 159 Multiple roles for DNA methylation in gametic imprinting Bjorn Neumann* and …

X chromosome inactivation in both mouse and human requires the presence of a cis acting
locus, the X inactivation centre. This locus is thought to be involved in the initiation and …

Xeroderma pigL. cttosu~ Cockay~ sy~ roma arul trichothiodystrophy are three distinct
human symlromes associated with sensitivity to uUratriolet radiattol We review evideace that …