Papillomavirus infections—a major cause of human cancers

H Zur Hausen - Biochimica et biophysica acta (BBA)-reviews on cancer, 1996 - Elsevier
The papillomavirus family represents a remarkably heterogeneous group of viruses. At
present, 77 distinct genotypes have been identified in humans and partial sequences have …

Papillomavirus-like particles and HPV vaccine development

JT Schiller, DR Lowy - Seminars in cancer biology, 1996 - Elsevier
Human papillomavirus-like particles (VLPs), self-assembled after high level expression of
the papillomavirus L1 virion capsid protein in non-mammalian cells, are attractive …

The natural history of human papillomavirus type 16 capsid antibodies among a cohort of university women

JJ Carter, LA Koutsky, GC Wipf… - Journal of Infectious …, 1996 - academic.oup.com
To study the temporal relationship between serum antibody response and human
papillomavirus type 16 (HPV-16) infection, a cohort of 325 university women were …

In vitro generation and type-specific neutralization of a human papillomavirus type 16 virion pseudotype

RB Roden, HL Greenstone, R Kirnbauer… - Journal of …, 1996 - Am Soc Microbiol
We report a system for generating infectious papillomaviruses in vitro that facilitates the
analysis of papillomavirus assembly, infectivity, and serologic relatedness. Cultured hamster …

In vitro synthesis of oncogenic human papillomaviruses requires episomal genomes for differentiation-dependent late expression.

MG Frattini, HB Lim, LA Laimins - Proceedings of the …, 1996 - National Acad Sciences
Human papillomavirus (HPV) types 16, 18, 31, and 51 are the etiologic agents of many
anogenital cancers including those of the cervix. These" high risk" HPVs specifically target …

Immunization with viruslike particles induces long-term protection of rabbits against challenge with cottontail rabbit papillomavirus

ND Christensen, CA Reed, NM Cladel, R Han… - Journal of …, 1996 - Am Soc Microbiol
Rabbits were immunized with recombinant baculovirus-produced virus-like particles (VLPs)
of cottontail rabbit papillomavirus (CRPV) to determine whether these antigens could induce …

Assessment of the serological relatedness of genital human papillomaviruses by hemagglutination inhibition

RB Roden, NL Hubbert, R Kirnbauer… - Journal of …, 1996 - Am Soc Microbiol
To assess the potential for cross-protection among genital human papillomavirus (HPV)
types in virus-like particle (VLP)-based vaccinations, inhibition of HPV VLP-mediated …

Conserved features in papillomavirus and polyomavirus capsids

DM Belnap, NH Olson, NM Cladel… - Journal of molecular …, 1996 - Elsevier
Capsids of papilloma and polyoma viruses (papovavirus family) are composed of 72
pentameric capsomeres arranged on a skewed icosahedral lattice (triangulation number of …

Roots and perspectives of contemporary papillomavirus research

H Hausen - Journal of cancer research and clinical oncology, 1996 - Springer
The second part of the past and the first decade of this century experienced an unanticipated
blossoming of research in the etiology of infectious diseases. The discovery of bacteria as …

Two amino acid residues confer type specificity to a neutralizing, conformationally dependent epitope on human papillomavirus type 11

SW Ludmerer, D Benincasa, GE Mark 3rd - Journal of virology, 1996 - Am Soc Microbiol
Characterization of virus binding by neutralizing antibodies is important both in
understanding early events in viral infectivity and in development of vaccines. Neutralizing …