The recent discovery of a P2X purinoceptor (a ligand-gated ion channel triggered by ATP)
that is selectively expressed by small-diameter sensory neurons has led to the exploration of …

The P2Z receptor is responsible for adenosine triphosphate (ATP)-dependent lysis of
macrophages through the formation of membrane pores permeable to large molecules …

The family of epithelial sodium channels and nematode degenerins has expanded recently
to include a member found only in brain, and another that functions in molluscs as a ligand …

Several P2X receptor subunits were recently cloned; of these, one was cloned from the rat
vas deferens (P2X1) and another from pheochromocytoma (PC12) cells differentiated with …

1. Complementary DNAs for the ATP‐gated ion channel subunits P2X1 (from human
bladder) and P2X2 (from rat phaeochromocytoma (PC12) cells) were used to express the …

ATP-gated ion channels (P2X receptors) are abundantly expressed in both neuronal and
nonneuronal tissues, where they can serve as postsynaptic receptors. The response to ATP …

In the immune system, apoptosis is involved in intrathymic elimination of self-reactive
thymocytes and in peripheral T cell tolerance to exogenous antigens. Here, we describe the …

▪ Abstract ATP and other nucleotides can be released from cells through regulated
pathways, or following the loss of plasma membrane integrity. Once outside the cell, these …

Over the last 3 years (March, 1993 to June, 1996), DNA sequences have been isolated for
some 40 proteins that act as P2 purinoceptors. This explosion in receptor subtypes for …

1. Fast excitatory postsynaptic currents (fEPSCs) and responses to exogenously applied
purinoceptor agonists were studied in primary cultures of myenteric neurons from guinea …