Binding of hypoglycemic sulfonylureas and their analogues to the sulfonylurea receptor in
the β-cell plasma membrane mediates closure of the ATP-sensitive K+-channel (K ATP …

Since the cloning of the first inwardly rectifying K+ channel in 1993, a family of related clones
has been isolated, with many members being expressed in the heart. Exogenous …

Molecular cloning together with functional characterization has shown that the newly
identified family of inwardly rectifying K+ channels consists of several closely related …

The weaver (wv) gene (GIRK2) is a member of the G-protein-gated inwardly rectifying
potassium (GIRK) channel family, known effectors in the signal transduction pathway of …

GABA and the GABAB receptor agonist baclofen activated a potassium conductance in
acutely dissociated hippocampal CA3 neurons. Baclofen-activated current required internal …

The weaver mutation corresponds to a substitution of glycine to serine in the H5 region of a
G protein–gated inwardly rectifying K+ channel gene (GIRK2). By studying mutant GIRK2 …

Dynamic regulation of ion channel interactions with the cytoskeleton mediates aspects of
synaptic plasticity, yet mechanisms for this process are largely unknown. Here, we report …

Kir 4.1 is an inward rectifier potassium channel subunit isolated from rat brain which forms
homomeric channels when expressed in Xenopus oocytes; Kir 5.1 is a structurally related …

We demonstrate here that coexpression of ROMK2, an inwardly rectifying ATP-sensitive
renal K+ channel (IKATP) with cystic fibrosis transmembrane regulator (CFTR) significantly …

Inwardly rectifying potassium channels have an important role in determining the resting
potential of the cell. They are tetrameric proteins with two transmembrane segments (M1 and …