Background Neural tube defects arise during the development of the brain and spinal cord.
Objectives The objective of this review was to assess the effects of increased consumption of …

As new antiepileptic drugs (AEDs) become available, physicians will define their appropriate
use in particular patient populations. For women, the issues in clude gender‐specific …

To inform choices about the future of epidemiology, the present condition of epidemiology is
examined, in terms of its evolution through three eras, each demarcated by its own …

The biological basis or mechanism whereby folate supplementation protects against heart
and neural tube defects is unknown. It has been hypothesized that the amino acid …

There is consistent evidence that the risk of neural tube defects is decreased by
periconceptional supplementation with folic acid. A similar protective effect has been …

Approximately 50% of neural tube defects may be folate-preventable and perhaps even
more in other countries where prevalence is high. The Public Health Service has issued the …

The role of periconceptional folic acid in the prevention of neural tube defects (NTDs) is well
established. However, it is not clear whether a protective effect exists for the subset of …

Methanol, which is detoxified via a folic acid‐dependent pathway, has been shown to be
teratogenic in mice. Given recent observations that the level of dietary folic acid intake may …

The prognostic value of maternal serum triple analyte screening with AFP, hCG and uE3
(unconjugated estriol) was studied early in the second trimester of pregnancy. In this case …

The objectives of this study were: to inform health professionals and women of childbearing
age about the prevention of neural tube defects by folate; to recommend that all women of …