Publisher Summary This chapter concentrates on the mechanisms by which the sympathetic
nervous system may be causally involved in the generation of pain and hyperalgesia …

Much progress has been made the understanding of endogenous pain controlling systems.
Recently, new concepts and ideas which are derived from neurobiology, chaos research …

Sensitization of primary afferent neurons underlies much of the pain and tenderness
associated with tissue injury and inflammation. The increase in excitability is caused by …

Pain differs from other sensations in many respects. Primary pain-sensitive neurons respond
to a wide variety of noxious stimuli, in contrast to the relatively specific responses …

Mast cells play a key role in inflammatory reactions triggered by tissue injury or immune
perturbations. Little is known about endogenous molecules and mechanisms capable of …

Substance P (SP), neurokinin A (NKA), and calcitonin gene-related peptide (CGRP) have
potent proinflammatory effects in the airways. They are released from sensory nerve endings …

There is now widespread recognition that psychosocial factors play a key role in the
aetiology, perpetuation, management and prevention of cumulative trauma disorders CTDs …

The action of Lignocaine on nociceptive transmission in the spinal cord has been studied in
vitro using ventral root potential (VRP) recordings from 10-12-day-old rat hemisected spinal …

During the past two decades, several revisions of the concepts underlying interneuronal
communication in the central nervous system (CNS) have been advanced. Our group has …

Chronic pain differs from acute pain in that it serves no useful function, causes suffering,
limits activities of daily living, and increases costs of healthcare payments, disability, and …