Until recently, biogerontology was a backwater of biology, but progress in the qualitative and
quantitative genetic analysis of longevity has led to a revolution in aging research. This …

Introduction 3. An overview of interleukin-6 3.1. Physiology and pathophysiology of
interleukin-6 3.2. Control of interleukin-6 promoter activity 3.2. Interleukin-6 structure and …

This study was designed to define the lipopolysaccharide (LPS) sensitivity of aged mice in
terms of lethality and cytokine production and to determine down-regulating responses of …

Aging has been associated with diminished lung function and increased susceptibility to
lung infection. To determine whether changes suggestive of immune dysregulation and …

To assess acute-phase proteins in relation to ageing, we measured serum concentrations of
C-reactive protein (CRP), serum amyloid-A protein (SAA), alpha-1 acid glycoprotein (AGP) …

Publisher Summary Considerable evidence indicates that oxidative damage to central
nervous system (CNS) contributes to the etiology of several neurodegenerative diseases. α …

Elderly-onset rheumatoid arthritis (EORA) is thought to be different from younger-onset
disease (YORA) for many reasons, including a more elevated acute phase response and a …

Peripheral blood mononuclear cells (PBMC) from 40 consecutive patients entering a
screening program on cognitive impairment were studiedin vitrowith respect to their …

At the cellular level, mutations in deoxyribonucleic acid (DNA) can lead to synthesis of
altered proteins which are unable to sustain specific cell functions, eventually leading to its …

Abstract Interleukin-6 (IL-6) can inhibit growth of a variety of tumors including B16 routine
melanoma. IL-6 levels increase with age and after ovariectomy or menopause. The adrenal …