Arterial smooth muscle cells (SMCs) are in a quiescent growth state under normal
physiological conditions, but they can be stimulated to proliferate and migrate from one …

A biologic role for the 72-kDa gelatinase A (matrix metalloproteinase 2; MMP-2), beyond
simple extracellular matrix turnover, was evaluated in glomerular mesangial cells. To …

Microvascular endothelial cell invasion into the fibrin provisional matrix is an integral
component of angiogenesis during wound repair. Cell surface receptors which interact with …

The term tissue remodeling describes transient or permanent changes in tissue architecture
that involve breaching of histological barriers such as basement membranes, basal laminae …

The formation of capillaries from preexisting blood vessels (angiogenesis) occurs in a
variety of normal and pathological conditions, including organ development, would healing …

The formation of microvascular sprouts during angiogenesis requires that endothelial cells
move through an extracellular matrix. Endothelial cells that migrate in vitro generate forces …

The expression of plasminogen activators and inhibitors was examined in denuded arteries.
Within 5 days, smooth muscle cells (SMCs) on the luminal surface expressed the mRNA for …

The development of hyperplasias, dysplasias, and mammary tumors has been studied
extensively in transgenic mice. It is now becoming clear that transgenes activate and …

Flk-1, a high-affinity signaling receptor for vascular endothelial growth factor (VEGF), is
strongly and specifically expressed on endothelial cells during embryonic development of …

Previous studies have shown that high glucose levels and diabetes induce an elevation in
protein kinase C (PKC) activity in vascular cells and tissues susceptible to diabetic …