The pharmaceutical approach to somatic gene therapy is based on consideration of a gene
as a chemical entity with specific physical, chemical and colloidal properties. The genes that …

To understand how DNA is released from cationic liposome/DNA complexes in cells, we
investigated which biomolecules mediate release of DNA from a complex with cationic …

We propose a mechanism for oligonucleotide (ODN) release from cationic lipid complexes
in cells that accounts for various observations on cationic lipid-nucleic acid-cell interactions …

Purpose. The aim of this study was to gain insight into the relation between the physical
characteristics of particles formed by a plasmid and a synthetic cationic polymer (poly (2 …

Throughout most of the history of modern therapeutics, drugs were equated with small
organic molecules. Pharmaceutical chemists both in industry and academia synthesized …

Stable cationic lipid/DNA complexes were formed by solubilizing cationic liposomes with 1%
octylglucoside and complexing a DNA plasmid with the lipid in the presence of detergent …

Purpose. To study the parameters influencing the intracellular trafficking of oligonucleotides
delivered by cationic 1, 2-dioleoyl-3-trimethylammonium-propane (DOTAP) lipids and to …

We recently demonstrated that cationic lipids, added in monomer or micellar form, bind to
DNA, resulting in the formation of a hydrophobic complex. This complex can serve as a well …

The naturally occurring polyamine spermidine was covalently conjugated with cholesterol,
resulting in a novel cationic compound that mediates efficient gene transfer into mammalian …

DNA vaccination has proved to be a generally applicable technology in various preclinical
animal models of infectious and noninfectious disease and several DNA vaccines have now …