The harderian gland is an orbital gland of the majority of land vertebrates. It is the only
orbital gland in anuran amphibians since the lacrimal gland develops later during …

Melatonin is being increasingly promoted as a treatment for “jet lag” and insomnia and has
been suggested to act as an antioxidant in vivo. The antioxidant and potential pro-oxidant …

The mechanisms involved in the regulation of melatonin synthesis in the pineal gland have
been extensively reviewed (2-7)(Fig. 1). The initial step in the synthesis of melatonin …

Peripheral blood samples were collected from human volunteers at 0 (5–10 min before), and
at 1 and 2 h after a single oral dose of 300 mg of melatonin. At each time point,(i) the …

The vertebrate pineal gland rhythmically produces melatonin, a hormone involved in
regulation of several physiological and behavioral processes. Melatonin is synthesized from …

The sympathetic innervation of the rat pineal gland was investigated, measuring the
norepinephrine (NE) release by on‐line in vivo microdialysis. NE was assayed using an …

Study Design Matched pairs of adolescent girls were used to compare serum melatonin
levels in adolescent patients and control subjects with idiopathic scoliosis during the day …

In order to investigate the influence of various environmental parameters on melatonin
excretion, the night-time urinary melatonin excretion of 16 healthy volunteers was measured …

Coordinated programmes of gene expression are central to the complex processes of cell
growth and differentiation. From extensive studies it has emerged that the basic features of …

Tryptophan (TRP) is the precursor of melatonin, the primary secretory product of the pineal
gland. Hepatic heme deficiency decreases the activity of liver tryptophan pyrrolase, leading …