To practice evidence-based medicine, physicians need data on the clinical effectiveness,
toxicity, convenience, and cost of new drugs compared with available alternatives. We give …

In growing numbers of pharmacoeconomic studies, techniques of economic evaluation such
as cost-effectiveness analy-sis are used to determine the additional cost at which a new …

The aim of an equivalence trial is to show the therapeutic equivalence of two treatments,
usually a new drug under development and an existing drug for the same disease used as a …

“So soon as ever she came into the room I recognized the affection, for there lay, across the
face from temple to temple, an oblong tumor almost closing both eyes.” Thus, JL Milton in …

The results of recent empirical investigations in research synthesis imply that research ethics
committees are behaving unethically by endorsing new research which is unnecessary and …

Objective: To assess the possible association between tacrine (Cognex, manufactured by
Parke-Davis, Morris Plains, NJ) dose and likelihood of nursing home placement (NHP) or …

This study was performed in order to determine concentration-effect, and graded and
quantal dose-response relationships for the clinical administration of intravenous (IV) …

Placebo-controlled trials are held by many, including regulators at agencies like the United
States Food and Drug Administration (FDA), to be the gold standard in the assessment of …

The use of statistics in medical research has been compared to a religion: it has its high
priests (statisticians), supplicants (journal editors and researchers), and orthodoxy (for …

The effect of placebo on the clinical course of systemic hypertension, angina pectoris, silent
myocardial ischemia, CHF, and ventricular tachyarrhythmias has been well described. In the …