Wnt proteins are now recognized as one of the major families of developmentally important
signaling molecules, with mutations in Wnt genes displaying remarkable phenotypes in the …

Estrogens are important for the development of the mammary gland and strongly associated
with oncogenesis in this tissue. The biological effects of estrogens are mediated through the …

The vertebrate transcription factors TCF (T cell factor) and LEF (lymphocyte enhancer
binding factor) interact with β-catenin and are hypothesized to mediate Wingless/Wnt …

In Drosophila, members of the frizzled family of tissue-polarity genes encode proteins that
are likely to function as cell-surface receptors of the type known as Wnt receptors, and to …

Frzb-1 is a secreted protein containing a domain similar to the putative Wnt-binding region of
the frizzled family of transmembrane receptors. Frzb-1 is widely expressed in adult …

In a 4-cell stage C. elegans embryo, signaling by the P 2 blastomere induces anterior–
posterior polarity in the adjacent EMS blastomere, leading to endoderm formation. We have …

This paper describes the identification of a new family of mammalian genes that encode
secreted proteins containing homology to the cysteine-rich ligand-binding domain found in …

The tissue polarity genes of Drosophila are required for correct establishment of planar
polarity in epidermal structures1, 2, which in the eye is shown in the mirror-image symmetric …

We isolated a Xenopus homolog of Frzb, a newly described protein containing an amino-
terminal Frizzled motif. It dorsalized Xenopus embryos and was expressed in the Spemann …

Wntgenes encode secreted proteins which are implicated in receptor-mediated cell–cell
signaling events important in embryogenesis, but the second messenger systems …