Neoplastic cells simultaneously harbor widespread genomic hypomethylation, more
regional areas of hypermethylation, and increased DNA-methyltransferase (DNA-MTase) …

DNA methylation is crucial for mammalian development because embryos that cannot
maintain normal methylation levels die after gastrulation. I propose that DNA methylation is …

Transcription factor Sp1 has been implicated in the expression of many genes. Moreover, it
has been suggested that Sp1 is linked to the maintenance of methylation-free CpG islands …

Gametic imprinting is a developmental process that induces parental-specific expression or
repression of autosomal and X-chromosome-linked genes,. The mouse Igf2r gene …

One of the most prevalent products of oxygen radical injury in DNA is 8-hydroxyguanosine.
Cells must be able to withstand damage by oxygen radicals and possess specific repair …

Promoter region CpG island methylation is associated with tumor suppressor gene silencing
in neoplasia. GenBank sequence analyses revealed that a number of CpG islands are …

Spl is one of the very first cellular transcription factors to be identified and cloned in virtue of
its binding to a Grich motif in the SV40 early promoter. Spl protein binds to the Grich …

In eukaryotic cells, the methylation state of the base cytosine can be inherited without
altering genetic material per se (1). This unusual—or “epigenetic”—form of inheritance …

Previously it has been found that binding of the Sp1 transcription factor is not significantly
affected by methylation of the CpG dinucleotide within its binding site, 5′-GGGCGG (lower …

The mouse Snrpn gene encodes the Smn protein, which is involved in RNA splicing. The
gene maps to a region in the central part of chromosome 7 that is syntenic to the Prader …