Obesity has now developed into a world-wide epidemic and is associated with large
economic costs and prevalent diseases, particularly with central body fat distribution. Insulin …

11beta-Hydroxysteroid dehydrogenases (11beta-HSDs) interconvert active corticosterone
and inert 11-dehydrocorticosterone. In tissue homogenates, 11beta-HSD type 1 (11beta …

We have studied the GH-insulin-like growth factor (IGF) axis in prepubertal children with
exogenous obesity at the time of clinical diagnosis and at two time points during weight …

Remarkable decreases in growth hormone (GH) secretion accompany healthy aging. The
pathophysiology of this hyposomatotropism is confounded by concurrent changes in body …

The acute effects of a single GH pulse have previously been studied in young males. It is,
however, likely that both the metabolic effects and the pharmacokinetics of GH may differ …

The syndrome associated with lack of growth hormone (GH) in adults can be reversed by
treatment with recombinant human GH (rhGH) with apparently beneficial clinical effects. This …

In anorexia nervosa, serum GH levels are increased under basal conditions and respond
abnormally to provocative stimuli. We report here, for the first time, an analysis of pulsatile …

The objectives of this study were to 1) study the GH-insulin-like growth factor (IGF) axis in
adult untreated Turner's syndrome compared to that in age-matched controls, 2) examine …

The circulating high affinity GH-binding protein (GHBP), which derives from the extracellular
domain of the hepatic GH receptor, correlates inversely to GH levels and directly to body …

OBJECTIVE Growth hormone (GH) secretion declines with age and is affected by body
composition. The signal that mediates the latter relationship remains ill‐defined. Leptin, the …