Technique to control pH in vicinity of biodegrading PLA‐PGA implants

CM Agrawal, KA Athanasiou - Journal of biomedical materials …, 1997 - Wiley Online Library
This in vitro study was performed to examine if the pH decrease in the vicinity of degrading
polylactic acid (PLA) and polyglycolic acid (PGA) polymers can be offset by incorporation of …

Elevated temperature degradation of a 50: 50 copolymer of PLA-PGA

CM Agrawal, D Huang, JP Schmitz… - Tissue …, 1997 - liebertpub.com
In vitro degradation studies of devices fabricated from polylactic acid (PLA) and polyglycolic
acid (PGA) are usually performed at the physiologic 37° C and often take long periods of …

Analysis of the influence of polymer characteristics and core loading on the in vivo release of a somatostatin analogue

A Rothen-Weinhold, K Besseghir, R Gurny - European Journal of …, 1997 - Elsevier
Peptides and proteins have received much attention in recent years as candidate drugs.
Vapreotide (RC-160) is a somatostatin analogue used for the therapy of hormone …

Autosterilization of biodegradable implants by injection molding process

C König, K Ruffieux, E Wintermantel… - Journal of biomedical …, 1997 - Wiley Online Library
Sterilization of degradable implants by standard procedures may damage the parts due to
the labile chemical nature of the polymers. This study examined whether the injection …

Resorption of composite polymer—hydroxyapatite membranes: a time-course study in rabbit

A Piattelli, M Franco, G Ferronato, MT Santello… - Biomaterials, 1997 - Elsevier
The histological findings, in rabbit, concerning the resorption of a new composite
hydroxyapatite-polymer membrane used in guided tissue regeneration are reported. The …

New generation of poly (ortho esters): synthesis, characterization, kinetics, sterilization and biocompatibility

M Zignani, A Merkli, MB Sintzel, SF Bernatchez… - Journal of controlled …, 1997 - Elsevier
After a brief historical overview of the development of three families of poly (ortho
esters)(POEs), the physico-chemical characteristics, drug release properties and …

Analysis of surface microtopography of biodegradable polymer matrices using confocal reflection microscopy

EJ Semler, JS Tjia, PV Moghe - Biotechnology progress, 1997 - Wiley Online Library
Currently, synthetic degradable polymers are frequently employed as culture substrates
prior to cell transplantation and as implantable scaffolds for cellular infiltration during soft …

[PDF][PDF] New radio-opaque polymeric biomaterials: synthesis, characterization and biomedical applications of iodine-containing methacrylate polymers

MAB Kruft - 1997 - research.tue.nl
Biomaterials are defined as substances, other than food or drugs, contained in therapeutic
or diagnostic systems that are used in contact with tissue or biological fluids. 1 There are …

[图书][B] Fabrication of pliable polymer scaffolds for tissue engineering and particulate effects on osteoblast function

MC Wake - 1997 - search.proquest.com
Pliable, biodegradable scaffolds with poly (lactic-co-glycolic acid)(PLGA) and poly (ethylene
glycol)(PEG) blends have been fabricated using a solvent-casting and particulate-leaching …

[图书][B] The effect of shear stress on a co-culture of endothelial cells and fibroblasts in a biodegradable polymer scaffold

LG Braddon - 1997 - search.proquest.com
One approach to the tissue engineering of a blood vessel substitute is to use a
biodegradable polymer as a scaffold into which fibroblasts can be seeded to form a …