The p53 tumor suppressor protein, that has a fundamental role in growth control and
neoplasia, has been one of the most extensively studied proteins in recent years. The first …

Loss of cell cycle control and increased genomic instability are characteristics of most tumor
cells. Activation of proto-oncogenes that promote cell growth in combination with the …

We describe a gene encoding p73, a protein that shares considerable homology with the
tumor suppressor p53. p73 maps to 1p36, a region frequently deleted in neuroblastoma and …

We have screened the p53 status of 156 human cell lines, including 142 tumor cell lines
from 27 different tumor types and 14 cell lines from normal tissues by using functional …

We recently reported the identification of a mouse cDNA encoding a new p53-associating
protein that we called Mdmx because of its structural similarity to Mdm2, a well-known p53 …

Abstract Heat shock (43 C, 45 min) induced transient nuclear accumulation of p53 in primary
human fibroblasts without any clonogenically toxic effects. The accumulation of p53 reached …

Multidrug resistance in MCF-7/Adr human breast cancer cells is mediated by several
mechanisms including overexpression of the MDR1 gene product, P-glycoprotein and …

Background: Retinoblastoma is the most common childhood tumor of the eye, arising from
cells that are defective in both copies of the retinoblastoma susceptibility gene (RB1). Most …

The effect of activated human K-ras on cell cycle proteins was studied by use of a stable
MCF-7 transfectant expressing inducible activated K-ras under the control of a tetracycline …

Human neuroblastoma is the most frequent solid tumor in children. Recent studies suggest
that a multiplicity of genomic alterations contributes to neuroblastoma, the most frequent and …