Nutrition has a strong influence on the immune system of the elderly. Aging induces
dysregulation of the immune system, mainly as a result of changes in cell-mediated …

The majority of patients with cancer in the United States are more than 70 years old. Despite
the increased understanding of the molecular bases for both oncogenesis and aging, the …

Background. IL-6 is a multifunctional cytokine that has been shown to increase with age.
Methods. Plasma IL-6 was measured by ELISA in 1,727 community-dwelling elderly …

Background. Substantial data from animal studies have demonstrated a stimulatory effect of
dehydroepiandrosterone (DHEA) on immune function. However, little is known about the …

The pathophysiology of many disease states observed in aged individuals has been linked
to the dysregulated production of several pleiotropic cytokines. We have demonstrated that …

Objective: To give a brief summary of age-related alterations that occur in the immune
system (immunosenescence), with special regard to the skin immune system. Data Sources …

Osteoporosis is a major cause of morbidity in older people. There are a large number of risk
factors for the development of osteoporosis. However, these risk factors eventually must …

Aging is associated with declines in multiple areas of immune function, but to date no single
mechanism has emerged as being responsible for all the observed changes. Many changes …

We have previously shown that physiological hormone differences related to pregnancy or
sex affect the age-related distribution of mononuclear cell populations during murine ageing …

Lifespan extension and reduction of age-related disease by calorie restriction (CR) are
among the most consistent findings in gerontological research. The well known effects of CR …