Few diseases have been affected more by the advent of antimicrobial therapy than bacterial
meningitis. From its recognition in 1805 to the early 20th century, bacterial meningitis was …

Inflammation in the subarachnoid space represents the pathological hallmark of bacterial
meningitis. The intrathecal accumulation of leukocytes, in response to bacterial pathogens …

Several studies suggest the involvement of the complement system in the pathophysiology
of traumatic brain injury (TBI). Since the intrathecal generation of anaphylatoxin C5a has …

Abstract Interleukin-10 (IL-10) is a cytokine with antiinflammatory effects. In a rabbit model of
meningitis, IL-10 was given intracisternally or intravenously to evaluate the impact on …

Parameters of inflammation during pneumococcal meningitis were determined in rabbits
after monocyte elimination by dichloromethylene diphosphonate (Cl2MDP)-containing …

To elucidate the role of cytokines in brain repair processes and in local inflammation after
neurosurgical procedures, cerebrospinal fluid (CSF) samples from 8 patients with intra-axial …

An immunoregulatory mechanism involving release of neutralizing autoantibodies (Aabs) to
self cytokines during bacterial infections is presented herein. Intraperitoneal inoculation of …

In pneumococcal meningitis inflammatory mediators such as tumor necrosis factor alpha
(TNFα) are produced in large quantities and play a major role in pathogenesis. It is not …

Intraperitoneal inoculation ofHaemophilus influenzaetype b (Hib) to 3-week-old Sprague–
Dawley rats resulted in nonlethal meningitis with high levels of leukocytes in the …

Objective and Design: We examined the involvement of IL-8 in TNFα and IL-1β neutrophil
infiltration, using homologous reagents.¶ Subjects: Female New Zealand white rabbits (n …