Neoplastic cells simultaneously harbor widespread genomic hypomethylation, more
regional areas of hypermethylation, and increased DNA-methyltransferase (DNA-MTase) …

A variety of phylogenetic measures have been proposed to quantify distinctiveness, often
held to mark species of high conservation worth. However, distinctiveness of species and …

In eukaryotic cells, the methylation state of the base cytosine can be inherited without
altering genetic material per se (1). This unusual—or “epigenetic”—form of inheritance …

DNA amplification is a common mechanism invoked by many human tumors to elicit
overexpression of genes whose products are involved in drug resistance or cell proliferation …

Genomic methylation patterns of mammals can vary among individuals and are subject to
dynamic changes during development. In order to gain a better understanding of this …

Subtractive cloning is a powerful technique for isolating genes expressed or present in one
cell population but not in another. This method and a related one termed positive selection …

Ataxia-telangiectasia (AT) is an autosomal recessive disorder involving cerebellar
degeneration, immunodeficiency, chromosomal instability, radiosensitivity, and cancer …

In this paper we present a mathematical model of mutation and selection that allows for the
coexistence of multiple alleles at a locus with very small selective differences between …

Cancer is often viewed as a genetic process in which the developing cancer cell acquires
successive mutational lesions that each provide the cell with a growth or survival advantage …

O6-Methylguanine-DNA methyltransferase (MGMT) is a DNA repair protein that transfers
methyl and alkyl lesions from the O6 position of guanine to a cysteine in its structure. The …