This article starts with a brief account of the history of research on pulmonary surfactant. We
will then discuss the morphological aspects and composition of the pulmonary surfactant …

Pulmonary alveolar proteinosis (PAP) is a heterogeneous disorder of genetic or acquired
etiologies. In some cases congenital PAP is associated with hereditary surfactant protein …

Objective: To evaluate lung transplantation for treatment of surfactant protein B (SP-B)
deficiency. Study design: We compared surfactant composition and function from …

Objective. To compare the relative safety and efficacy of Infasurf (calf lung surfactant extract;
ONY, Inc, Amherst, NY, IND# 27169) versus Survanta (Beractant, Ross Laboratories …

Genetic ablation of the murine SP-B gene in transgenic mice caused lethal perinatal
respiratory distress in homozygous offspring, whereas heterozygous SP-B (+/-) mice …

(CHEST 1997; 111: 129S) prostacyclin synthase (PGIS) is the final committed enzymatic
step in the pathway of prostacyclin (PGI2) production, occurring at a branch point where …

The function of the 102-amino acid C-terminal propeptide of surfactant protein B (SP-B) was
analyzed by characterizing the phenotype associated with loss of expression of this peptide …

Aaron Hamvas, MD ulmonary surfactant is a complex mixture of p phospholipid and protein
that is synthesized--by alveolar type II pneumocytes and is necessary to maintain alveolar …

Congenital alveolar proteinosis is a recently described cause of lung dysfunction and
respiratory distress in term neonates. In several cases a deficiency or insufficiency of …

Pulmonary surfactant is a complex mixture of phospholipid and protein that is synthesized by
alveolar type II pneumocytes and is critical for maintaining alveolar expansion at end …