Nociceptin/orphanin FQ and the opioid receptor-like ORL1 receptor

JC Meunier - European journal of pharmacology, 1997 - Elsevier
Homology cloning and, more recently, the sequencing of whole genomes, have identified
many open reading frames encoding proteins of unknown function, in particular putative G …

The orphan opioid receptor and its endogenous ligand—nociceptin/orphanin FQ

G Henderson, AT McKnight - Trends in pharmacological sciences, 1997 - cell.com
Following the elucidation of the amino acid sequences of the μ-, δ-and κ-opioid receptors, a
new 'orphan opioid receptor'was cloned with a high degree of homology to the …

Pharmacological characterization of orphanin FQ/nociceptin and its fragments

GC Rossi, L Leventhal, E Bolan… - Journal of Pharmacology …, 1997 - ASPET
The cloning of a fourth member of the opioid receptor family has led to the discovery of a
new neuropeptide termed orphanin FQ or nociceptin (OFQ/N). Studies in CD-1 mice confirm …

Orphan anxiety

JR Walker, GF Koob - … of the National Academy of Sciences, 1997 - National Acad Sciences
The recent discovery of several new endogenous opioid peptides has generated excitement
over their potential physiological roles. For example, endomorphins are likely to have well …