▪ Abstract While still incomplete, the first data concerning the biochemistry of T cell receptor–
ligand interactions in cell-free systems seem to have considerable predictive value …

Publisher Summary This chapter discusses the immunoregulatory functions of γδ T cells. γδ
T cells are studied extensively in both mice and humans. The chapter focuses mostly on …

Human γδ T lymphocytes represent a minor subset of T cells in the peripheral blood, which
exhibit a limited diversity and a tissue-restricted repertoire in contrast to their broad …

Human γδ T cells recognize prenyl pyrophosphate Ags and their analogues in a Vγ2Vδ2
TCR-dependent manner. Few data are available regarding the TCR structural requirements …

Antigen recognition by T lymphocytes is mediated by cell-surface glycoproteins known as T-
cell antigen receptors (TCRs). These are composed of α and β, or γ and δ, polypeptide …

The number of γδ T cells in the peritoneal cavity was increased after an intraperitoneal (ip)
infection with Escherichia coli in lipopolysaccharide (LPS)-responsive C3H/HeN mice but …

Despite the description of numerous antigenic ligands recognized by TCRγδ cells, detailed
information concerning the structural nature of these antigenic epitopes is lacking. In …

Lyme arthritis synovial fluid contains a large proportion of γδ T cells that proliferates upon
stimulation with the causative spirochete, Borrelia burgdorferi. A panel of Borrelia-reactive …

Recent studies have demonstrated increased numbers of γδ T cells in a variety of human
infectious as well as noninfectious diseases. In some cases γδ T cells could be shown to …

We examined the functional and molecular parameters involved in direct TCR recognition of
a tumor-specific peptide epitope on the tumor Ag MUC1. This peptide epitope is tandemly …