Background Polymorphic eruptions of pregnancy (PEP) are common cutaneous disorders of
unknown origin that occur usually after week 34 of gestation. Since pregnancy is associated …

Accurate surveillance of intrauterine growth is a principal task in perinatal care. The
identification of growth abnormalities hinges on the application of an appropriate growth …

OBJECTIVE: Currently, prenatal diagnosis of chromosome abnormalities requires invasive
techniques such as amniocentesis and chorionic villus sampling that carry small but finite …

Fetal male DNA can be identified in maternal blood by polymerase chain reaction (PCR)
amplification of Y-specific sequences. This technology has not reached a satisfactory …

Prenatal diagnosis of genetic abnormalities requires nucleated fetal cells which are currently
obtained by invasive techniques such as amniocentesis, chorionic villus sampling and …

It is a long-term goal of human genetics to develop prenatal diagnostic tests that are
noninvasive and which do not constitute a risk to the mother or fetus. Such tests would be …

The polymerase chain reaction (PCR) was first described by Mullis et al. in 1985. 1 Once
thermostable DNA polymerases were discovered? the techniques of molecular biology and …

Each year in this country there are about 800,000 deliveries'. Forty thousand will be born to
women over the age of 35 years to whom prenatal diagnosis will usually be offered because …