BACKGROUND Microsatellite instability (MIN) has been identified in a wide variety of
human tumors, both familial and sporadic. In this study the authors attempted to correlate …

Loss of heterozygosity (LOH) at the mannose 6-phosphate/insulin-like growth factor 2
receptor gene locus (M6P/IGF2R) on 6q26-27 has recently been demonstrated in …

Background—Up to 15% of colorectal cancers are characterised by DNA microsatellite
instability (MIN), shown by the presence of DNA replication errors (RERs). Aims—To identify …

The role, if any, that mitochondrial (mt) DNA alterations play in the carcinogenic process
remains unclear. To determine whether mtDNA instability occurs in cancers, nine …

A subset of hereditary and sporadic colorectal carcinomas is defined by microsatellite
instability (MSI), but the spectra of gene mutations have not been characterized extensively …

Gastric carcinomas with DNA replication errors (RER phenotype) display a particular
clinicopathologic profile and carry a putative favorable prognosis. The RER phenotype has …

Disruption of the DNA mismatch repair system, characterized by microsatellite instability
(MI), plays an important role in the course of human carcinogenesis by increasing the rate of …

Microsatellite instability (MSI) has been identified in various human cancers, particularly
those associated with the hereditary nonpolyposis colorectal cancer syndrome. Although …

To determine whether loss of mismatch repair (MMR) confers sensitivity to N-(2-chloroethyl)-
N′-cyclohexyl-N-nitrosourea (CCNU), the sensitivity of MMR-defective (MMR-) variants was …

The genomes of all organisms contain an abundance of DNA repeats which are at-risk for
causing genetic change. We have used the yeast Saccharomyces cerevisiae to investigate …