Extracellular purines (adenosine, ADP, and ATP) and pyrimidines (UDP and UTP) are
important signaling molecules that mediate diverse biological effects via cellsurface …

Anedoctal evidence accumulated over almost 20 years has shown that many different cell
types are killed by sustained exposure to high concentrations of extracellular ATP. The …

Nephropathic cystinosis, an autosomal recessive disorder resulting from defective lysosomal
transport of cystine, is the most common inherited cause of renal Fanconi syndrome. The …

We have studied the distribution and regulation of the P2X3receptor (a ligand-gated ion
channel activated by ATP) in adult dorsal root ganglion (DRG) neurons using a polyclonal …

The P2X3 receptor subunit, a member of the P2X family of ATP‐gated ion channels, is
almost exclusively localized in sensory neurons. In the present study, we sought to gain …

Kuriyama, H., K. Kitamura, T. Itoh, and R. Inoue. Physiological Features of Visceral Smooth
Muscle Cells, With Special Reference to Receptors and Ion Channels. Physiol. Rev. 78: 811 …

Ionotropic ATP receptors are widely expressed in mammalian CNS. Despite extensive
functional characterization of neuronal homomeric P2X receptors in heterologous …

The distribution of P2X1, P2X2, P2X3, P2X4, P2X5 and P2X6 receptors, a family of ATP-
gated cation channels, in rat trigeminal, dorsal root, nodose, superior cervical, and coeliac …

Extracellular nucleotides have been implicated in a number of physiological functions.
Nucleotides act on cell-surface receptors known as P2 receptors, of which several subtypes …

ATP analogs substituted in the γ-phosphorus (ATPγS, β, γ-imido-ATP, and β, γ-methylene-
ATP) were used to probe the involvement of P2 receptors in the modulation of synaptic …