▪ Abstract The luteinizing hormone receptor (LHR) is a member of the subfamily of
glycoprotein hormone receptors within the superfamily of G protein–coupled receptor …

Objective: To present an overview of potential etiologies, clinical manifestations, and
treatment modalities of premature ovarian failure (POF). Design: A search of past and …

Premature ovarian failure is a condition characterized by amenorrhea, infertility, sex steroid
deficiency, and elevated gonadotropins in women less than 40 years of age. 71 It affects 1 …

A single natural loss of function mutation of the follicle stimulating hormone receptor (FSHR)
has been described to date. Present in the Finnish population it markedly impairs receptor …

Normal pubertal development and fertility depend on the intricate interplay of hypothalamic,
pituitary, and gonadal factors. Crucial in this respect are normal secretory patterns of follicle …

Our understanding of the regulation of the menstrual cycle has recently improved with the
development of various tools of investigation. The cycle is now thought to be determined …

Mammalian sex determination involves complex interacting networks of cellular and
hormonal signals leading to the development of male or female phenotypes. Three main …

In the human male fetus, testes develop by the 7th week and begin to secrete two hormones:
anti-müllerian hormone (AMH) induces the regression of müllerian ducts, the anlagen of the …

In this report, the genomic DNA was examined from two siblings with gonadal LH resistance.
A 46, XY pseudohermaphrodite presented with female external genitalia and his 46, XX …

Leydig cell hypoplasia (LCH) is characterized by a decreased response of the Leydig cells
to LH. As a result, patients with this syndrome display aberrant male development ranging …