Cytokines participate in the induction and effector phases of all immune and inflammatory
responses. They are therefore obvious tools and targets for strategies designed to promote …

Chemokines play an important role in the regulation of endothelial cell (EC) function,
including proliferation, migration and differentiation during angiogenesis, and re …

We have cloned a TNFR family member from a follicular dendritic cell (FDC)-like cell line,
FDC-1. This molecule, FDC-derived receptor-1 (FDCR-1), is identical to osteoprotegerin …

Interleukin-8, a member of the CXC chemokine family, has been shown to bind to
glycosaminoglycans. It has been suggested that heparan sulfate on cell surfaces could …

Interleukin (IL)-8, a CXC chemokine, activates integrin-mediated adhesion of neutrophils.
Presentation of IL-8 on the endothelial cell surface may promote leukocyte extravasation …

Leukocyte adhesion molecules are critically involved at a number of stages in immune and
inflammatory responses, and their importance in the response to a renal allograft has been …

Alcoholic liver disease is associated with three histologically distinct processes: steatosis
(parenchymal fat accumulation), alcoholic hapatitis (characterized by parenchymal …

In addition to its role in mediating leukocyte adherence to and migration across the
endothelium, intercellular adhesion molecule (ICAM)-1 on the surface of interstitial cells has …

Heparan sulfate is rapidly degraded by an endoglycosidase (heparanase) secreted by
activated platelets. Since the cleavage and release of heparan sulfate would profoundly …

Migration of inflammatory cells requires cell adhesion and their subsequent detachment
from the extracellular matrix (ECM). Leukocyte activation and migration must be terminated …