Human toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide

CJ Kirschning, H Wesche, T Merrill Ayres… - The Journal of …, 1998 - rupress.org
Bacterial lipopolysaccharide (LPS) induces activation of the transcription factor nuclear
factor κB (NF-κB) in host cells upon infection. LPS binds to the glycosylphosphatidylinositol …

Genetic and physical mapping of theLpsLocus: identification of the Toll-4 receptor as a candidate gene in the critical region

A Poltorak, I Smirnova, X He, MY Liu… - Blood Cells, Molecules …, 1998 - Elsevier
On the basis of 2093 meioses analyzed in two separate intraspecific backcrosses, the
location of the mouseLpsdmutation was circumscribed to a genetic interval 0.9 cM in size. A …

Divergent effects of LPS on expression of IL-1 receptor family members in mononuclear phagocytes in vitro and in vivo

S Saccani, N Polentarutti, G Penton-Rol, JE Sims… - Cytokine, 1998 - Elsevier
Three molecules, interleukin 1 (IL-1) receptor I (IL-1RI), IL-1 receptor II (IL-1RII or decoy) and
IL-1 receptor accessory protein (IL-1R AcP or IL-1RIII), are involved in IL-1 binding and …