The skeleton's primary mechanical function is to provide rigid levers for muscles to act
against as they hold the body upright in defiance of gravity. Many bones are exposed to …

Les ostéoblastes sont des cellules squelettiques effectuant la synthèse, la dépôt et la
minéralisation de la matrice extracellulaire de l'os. Par des mécanismes commençant à …

Homozygous mice with a null mutation in the MMP-9/gelatinase B gene exhibit an abnormal
pattern of skeletal growth plate vascularization and ossification. Although hypertrophic …

Cumulative evidence indicates that osteoblasts and adipocytes share a common
mesenchymal precursor and that bone morphogenetic proteins (BMPs) can induce both …

The mammalian AML/CBFα runt domain (RD) transcription factors regulate hematopoiesis
and osteoblast differentiation. Like their Drosophila counterparts, most mammalian RD …

Extracellular matrix molecules such as type I collagen are required for the adhesion,
migration, proliferation, and differentiation of a number of cell types including osteoblasts …

The AML1 transcription factor and the transcriptional coactivators p300 and CBP are the
targets of chromosome translocations associated with acute myeloid leukemia and …

Bone remodeling depends on the spatial and temporal coupling of bone formation by
osteoblasts and bone resorption by osteoclasts; however, the molecular basis of these …

Extensive analysis during the last 10–15 years has identified many of the mechanisms and
factors involved in the activation of eukaryotic gene transcription. Although activation is …

ABSTRACT In Hoxa-2−/− embryos, the normal skeletal elements of the second branchial
arch are replaced by a duplicated set of first arch elements. We show here that Hoxa-2 …