Phosphoinositide 3-kinases are a family of lipid kinases that phosphorylate the 3′ position
of the inositol ring on phosphatidylinositol and higher-phosphorylated …

Observation of the flow of material along the endocytic pathway has lead to the description
of the basic architecture of the pathway and provided insight into the relationship between …

We have examined the roles of the p85/p110α and hVPS34 phosphatidylinositol (PI) 3′-
kinases in cellular signaling using inhibitory isoform-specific antibodies. We raised anti …

In the body, secretory granules can store a physiological agent (histamine, for instance) and
on stimulation can release it in the right place at the right time. Following that example, a …

Within the past ten years, inositol lipids have increasingly been implicated in membrane-
transport processes. Three studies now show what connects one inositol lipid …

During receptor-mediated endocytosis, ligands bind to their receptors and are incorporated
into clathrin coated vesicles. These vesicles bud from the plasma membrane, shed their …

Figure 1 Membrane-transport events that rely on proteins containing the FYVE finger
domain.(Red boxes indicate proteins with FYVE domains.) Early endosomal autoantigen …