The influence of the bolus injection rate of propofol on its cardiovascular effects and peak blood concentrations in sheep

D Zheng, RN Upton, AM Martinez, C Grant… - Anesthesia & …, 1998 - journals.lww.com
The influence of the bolus injection rate of propofol on its cardiovascular effects has not
been extensively studied. We therefore examined the influence of the injection rate of IV …

The effect of rate of administration on brain concentrations of propofol in sheep

GL Ludbrook, RN Upton, C Grant… - Anesthesia & …, 1998 - journals.lww.com
A marked reduction in the dose of propofol required to achieve the onset of anesthesia with
slower administration rates has previously been reported, but the mechanism of this …

The enantiomer-specific kinetics and dynamics of verapamil after rapid intravenous administration to sheep: physiological analysis and modeling

YF Huang, RN Upton, D Zheng, C Mclean… - … of Pharmacology and …, 1998 - ASPET
The lung, myocardial and systemic kinetics of the enantiomers of verapamil, and their
myocardial effects, were measured after administration of 10 mg of racemic verapamil during …

Cardiovascular and pulmonary interactions in pharmacokinetics

JA Kuipers, F Boer - Physiology And Pharmacology of Cardio-Respiratory …, 1998 - Springer
The fate of drugs in the body is dependent on the physical transport processes in the body.
These transport processes are initiated by the flow of blood in the greater and lesser …

[引用][C] LUNGS ARTERIAL BLOOD VENOUS BLOOD HEART LIVER INTESTINE

VB HEART - Physiology And Pharmacology of Cardio-Respiratory …, 1998 - Springer