The inhibitor of apoptosis protein family has been characterized over the past 5 years,
initially in baculovirus and more recently in metazoans. The IAPs are a widely expressed …

The sphingomyelin (SM) pathway is a ubiquitous, evolutionarily conserved signalling system
analogous to conventional systems such as the cAMP and phosphoinositide pathways …

Oxidative stress is implicated in neuronal apoptosis that occurs in physiological settings and
in neurodegenerative disorders. Superoxide anion radical, produced during mitochondrial …

Uric acid is a well‐known natural antioxidant present in fluids and tissues throughout the
body. Oxyradical production and cellular calcium overload are believed to contribute to the …

HPLC with electrochemical array detection (HPLC-ECD) was used to quantify 3, 3′-
dityrosine (diTyr) and 3-nitrotyrosine (3-NO2-Tyr) in four regions of the human brain that are …

Oxyradicals attack double bonds of unsaturated fatty acids in cell membranes in a process
called membrane lipid peroxidation (MLP). This process occurs in many different acute and …

Patients infected with HIV-1 often exhibit cognitive deficits that are related to progressive
neuronal degeneration and cell death. The protein Tat, which is released from HIV-1 …

The bacterial alkaloid staurosporine is widely employed as an inducer of apoptosis in many
cell types including neurons. The intracellular cascades that mediate staurosporine‐induced …

Increasing evidence indicates that neurons die by apoptosis, an active form of cell death
involving a relatively stereotyped series of biochemical changes that culminate in nuclear …

Many cases of autosomal dominant inherited forms of early‐onset Alzheimer's disease are
caused by mutations in the genes encoding presenilin‐1 (PS‐1; chromosome 14) and …