Forced expression of gap junction proteins, connexins, enables gap junction-deficient cell
lines to propagate intercellular calcium waves. Here, we show that ATP secretion from the …

Cystic fibrosis (CF) has become a paradigm disorder for the clinical testing of gene therapies
in the treatment of inherited disease. In recent years, efforts directed at gene therapy of CF …

Recently, it was reported that rabbit and human red blood cells (RBCs) release ATP in
response to mechanical deformation. Here we investigate the hypothesis that the activity of …

Purines can modify ciliary epithelial secretion of aqueous humor into the eye. The source of
the purinergic agonists acting in the ciliary epithelium, as in many epithelial tissues, is …

The cystic fibrosis transmembrane conductance regulator (CFTR) forms a tightly regulated
channel that mediates the passive diffusion of Cl− ions. Here we show, using macroscopic …

▪ Abstract Chloride channels are widely expressed and play important roles in cell volume
regulation, transepithelial transport, intracellular pH regulation, and membrane excitability …

The cystic fibrosis (CF) transmembrane regulator (CFTR) is a cyclic AMP-dependent Cl−
channel that is defective in CF cells. It has been hypothesized that CFTR exhibits an ATP …

The cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride channel that
is defective in cystic fibrosis, and has also been closely associated with ATP permeability in …

The cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride channel that
is regulated by phosphorylation of the R domain and ATP hydrolysis at two nucleotide …

CFTR is a cyclic AMP (cAMP)-activated chloride (Cl−) channel and a regulator of outwardly
rectifying Cl− channels (ORCCs) in airway epithelia. CFTR regulates ORCCs by facilitating …