Cytolytic T lymphocytes (CTLs) kill intracellular pathogens by a granule-dependent
mechanism. Granulysin, a protein found in granules of CTLs, reduced the viability of a broad …

Publisher Summary This chapter reviews the generation and TAP-mediated transport of
peptides for major histocompatibility complex class I molecules. The translocation of …

Bacterial infections activate complex T cell populations that differ in size and antigen
specificity. We used tetramerized MHC class I molecules complexed with Listeria …

Bacterial pathogens synthesize numerous proteins that are either secreted or localized
within bacterial cells. To address the impact of antigen compartmentalization on T cell …

Listeria monocytogenes is an intracellular bacterial pathogen that elicits a strong cellular
immune response following infection and therefore has potential use as a vaccine vector …

Infection of BALB/c mice with Listeria monocytogenes primes CD8+ cytotoxic T cells specific
for four different H2-K d-restricted peptides. In vitro restimulation of L. monocytogenes …

In an attempt to study codon usage effects of DNA vaccines on the induction of MHC class I-
restricted T cell responses against an intracellular bacterium, Listeria monocytogenes, we …

Using a strain of Listeria monocytogenes that stably expresses and secretes HIV gag to
deliver this Ag to the MHC class I pathway of Ag processing, we have identified the …

CD8+ T cells are effective mediators of immunity against Listeria monocytogenes, but the
mechanisms by which they provide antilisterial immunity are poorly understood. CD8+ T …

Listeria monocytogenes is a gram-positive, non-spore-forming bacterium that is ubiquitous
in nature. It is a facultative intracellular pathogen capable of causing disease in domestic …