Asthma is a complex chronic inflammatory disease of the airways that involves the activation
of many inflammatory and structural cells, all of which release inflammatory mediators that …

Nitric oxide (NO) is a potent biologic mediator with diverse physiologic and pathophysiologic
roles. NO is produced from L-arginine by the family of nitric oxide synthase (NOS) enzymes …

Cigarette smoking is associated with impaired endothelium-dependent vasodilation and
reduced nitric oxide (NO) in the exhaled air of smokers. To explore the mechanism for the …

In this study, we show that oxygen regulates nitric oxide (NO) levels through effects on NO
synthase (NOS) enzyme kinetics. Initially, NO synthesis in the static lung was measured in …

Since its initial discovery as an endogenously produced bioactive mediator, nitric oxide (•
NO) has been found to play a critical role in the cellular function of nearly all organ systems …

The role of nitric oxide (NO) in lung injury remains unclear. Both beneficial and detrimental
roles have been proposed. In this study, we used mutant mice lacking the inducible nitric …

Primary pulmonary hypertension (PPH) is a rare and fatal disease of unknown etiology.
Inflammatory oxidant mechanisms and deficiency in nitric oxide (NO) have been implicated …

Nitric oxide (NO) plays important roles in physiology and pathology. This small molecule
regu-lates smooth muscle tone, functions as a neuro-transmitter, regulates cellular …

Oxidative processes play an important role in atherogenesis. Because superoxide anion
and nitric oxide (NO) are important mediators in vascular pathology, we studied the …

Exhaled nitric oxide (NO) is elevated in asthmatics, and varies with disease severity. We
postulated that a respiratory virus infection increases exhaled NO levels in asthma, and …