Acute and chronic alveolar and/or bronchial inflammation is thought to be central to the
pathogenesis of many lung disorders such as asthma, chronic obstructive pulmonary …

Green tea polyphenols are potent antioxidants. They have both anti-cancer and anti-
inflammatory effects. However, their mechanisms of actions remain unclear. In inflammation …

Background Oxidant stress is a purported mechanism of tissue damage in patients with
ARDS and acute lung injury (ALI). Isoprostanes, prostanoid compounds primarily formed …

We evaluated the effect of the antioxidant N-acetylcysteine (NAC) on oxidative stress, lung
damage, and mortality induced by an endotoxin (lipopolysaccharide, or LPS) in the rat …

Hypertonic resuscitation fluids are known to be effective in restoring circulating volume in the
hypovolemic trauma patient. Previous studies have suggested that hypertonicity might exert …

Recent studies have suggested that hemorrhagic shock followed by resuscitation renders
patients more susceptible to lung injury by priming for an exaggerated response to a second …

The working hypothesis of the studies described herein was that inhibition of proteasome-
mediated IκB degradation would inhibit TNF-α-induced nuclear factor-κB (NF-κB) activation …

The development of acute lung inflammatory injury induced by alveolar deposition of IgG
immune complexes in rats requires increased production of the proinflammatory cytokines …

Background. Nuclear factor-κB (NF-κB) is a rapid response transcription factor for genes
whose products are critical for inflammation and immunity. In a rat model of heterotopic …

Human lungs accumulate iron with the aging process. In some circumstances associated
with lung injury (eg, smoking), this acquisition of iron in lung tissue and alveolar …