The synuclein gene family recently came into the spotlight, when one of its members, α-
synuclein, was found to be mutated in several families with autosomal dominant Parkinson's …

The abnormal aggregation of proteins into fibrillar lesions is a neuropathological hallmark of
several sporadic and hereditary neurodegenerative diseases. For example, Lewy bodies …

Two mutations in the gene encoding α-synuclein have been linked to early-onset
Parkinson's disease 1, 2, 3 (PD). α-Synuclein is a component of Lewy bodies, the fibrous …

α-Synuclein forms the major component of Lewy bodies and Lewy neurites, the defining
neuropathological characteristics of Parkinson's disease and dementia with Lewy bodies …

Recently, α‐synuclein was shown to be a structural component of the filaments in Lewy
bodies (LBs) of Parkinson's disease (PD), dementia with LBs (DLB) as well as the LB variant …

Missense mutations in the α-synuclein gene cause familial Parkinson's disease (PD), and α-
synuclein is a major component of Lewy bodies (LBs) in sporadic PD, dementia with LBs …

The presynaptic protein α-synuclein has been implicated in the pathogenesis of Parkinson's
disease. First, two missense mutations A30P and A53T cause inheritable early onset …

Recently two point mutations in the α-synuclein gene have been found in familial
Parkinson's disease. The characteristic fibrous neuropathological lesions of Parkinson's and …

α-Synuclein (α-syn) protein and a fragment of it, called NAC, have been found in association
with the pathological lesions of a number of neurodegenerative diseases. Recently …

Recently, we have shown that the precursor of the non-Aβ component of Alzheimer's
disease amyloid (NACP), also known as α-synuclein, is a major component of Lewy bodies …