Multiple isoforms of the Na+/H+ exchanger (NHE) are expressed at high levels in gastric
epithelium, but the physiological role of individual isoforms is unclear. To study the function …

Administration of inhibitors of the Na+/H+ exchanger (NHE) have been shown to produce
cardioprotective effects in a number of animal models of ischemia-reperfusion injury; …

Current opinions on the relationships between erythrocyte sodium-lithium countertransport
kinetics and primary hypertension, hyperlipidaemia and diabetic nephropathy are reviewed …

Mammalian Na+/H+ exchangers (NHEs) are a family of transport proteins (NHE1–NHE5). To
date, the cellular and subcellular localization of NHE4 has not been characterized using …

The Na+/H+ antiporter in vacuolar membranes transports Na+ from the cytoplasm to
vacuoles using a pH gradient generated by proton pumps; it is considered to be related to …

Na+ retention by the colon in response to salt deprivation is mediated in part by the resulting
secondary hyperaldosteronism. We show that experimental hyperaldosteronism, to levels …

Intestinal neutral NaCl absorption, which is made up of brush-border (BB) Na+/H+ exchange
linked to BB Cl−/HCO 3− exchange, is up-and downregulated as part of digestion and …

This study investigated the effect of chronic hypertonicity on the OKP cell Na/H antiporter,
encoded by Na/H exchanger 3 (NHE3). Chronic (48 h) increases in extracellular glucose …

We examined the regulation of the Na+/H+ exchangers (NHEs) NHE2 and NHE3 by
expressing them in human intestinal C2/bbe cells, which spontaneously differentiate and …

Experimental data indicate that the relatively hydrophilic carboxyl-terminal domains of Na+-
H+ exchangers mediate the regulation of transporter activity through interactions with …