Work reported over the past year has provided insights into the mechanisms whereby ligand
activation of the nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) …

The peroxisome proliferator-activated receptor-γ (PPAR-γ) is a member of the nuclear
receptor superfamily of ligand-dependent transcription factors that is predominantly …

Steroid hormones exert profound effects on differentiation, development, and homeostasis in
higher eukaryotes through interactions with nuclear receptors. We describe a novel orphan …

The cytochrome P-450 monooxygenase 3A4 (CYP3A4) is responsible for the oxidative
metabolism of a wide variety of xenobiotics including an estimated 60% of all clinically used …

Adipose differentiation is an important part of the energy homeostasis system of higher
organisms. Recent data have suggested that this process is controlled by an interplay of …

Dietary fatty acids specifically modulate the onset and progression of various diseases,
including cancer,, atherogenesis, hyperlipidaemia, insulin resistance and hypertension, as …

The expression patterns of the three different peroxisome proliferator-activated receptor
(PPAR) isotypes have been determined during rat embryonic development by in situ …

The orphan receptor CAR-β binds DNA as a heterodimer with the retinoid-X receptor and
activates gene transcription in a constitutive manner. Here we show that, in contrast to the …

The α-isoform of the peroxisome proliferator-activated receptor (PPARα) is a nuclear
transcription factor activated by structurally diverse chemicals referred to as peroxisome …

Peroxisomal β-oxidation system consists of four consecutive reactions to preferentially
metabolize very long chain fatty acids. The first step of this system, catalyzed by acyl-CoA …